IBT Publications by Loewe


Journal Articles (18)

A. Loewe, and O. Dössel.
Commentary: Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study.
In Frontiers in Physiology, vol. 8, pp. 1113, 2017
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
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A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
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A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
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A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
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A. Loewe, E. M. Wülfers, and G. Seemann.
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
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M. Alessandrini, M. Valinoti, L. Unger, T. Oesterlein, O. Dössel, C. Corsi, A. Loewe, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.
In Frontiers in Physiology, vol. 9, pp. 1251, 2018
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R. Andlauer, G. Seemann, L. Baron, O. Dössel, P. Kohl, P. Platonov, and A. Loewe.
Influence of Left Atrial Size on P-Wave Morphology - Differential Effects of Dilation and Hypertrophy.
In Europace, 2019
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O. Dössel, and A. Loewe.
Computerized modeling of the human heart.
In Zeitschrift für Medizinische Physik, vol. 27(3) , pp. 167-169, 2017
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O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
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H. Lehrmann, A. S. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel Electrocardiographic Criteria for Real-Time Assessment of Anterior Mitral Line Block.
In JACC: Clinical Electrophysiology, vol. 4(7) , pp. 920-932, 2018
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G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
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T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
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T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
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S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, 2018
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S. Pollnow, J. Greiner, T. Oesterlein, E. M. Wülfers, A. Loewe, and O. Dössel.
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
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B. Verma, T. Oesterlein, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
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Conference Contributions (58)

A. Loewe, R. Andlauer, P. G. Platonov, O. Dössel, and G. Seemann.
Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
In Computing in Cardiology, vol. 43, pp. 1-4, 2016
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A. Loewe, R. Andlauer, S. Pollnow, J. Greiner, T. G. Oesterlein, G. Seemann, and O. Dössel.
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size.
In Biomedizinische Technik, vol. 61, pp. S223, 2016
  
  
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by site of earliest right atrial activation.
In Cardiac Physiome Project, 2016
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by the site of earliest right atrial activation independent from atrial size in silico.
In International Conference on Electrocardiology, 2016
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A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
P-wave morphology is affected by site of earliest right atrial activation: a simulation study.
In TRM Forum, 2015
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
In Lecture Notes in Computer Science, vol. 9126, pp. 439–447, 2015
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A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Severe sinus bradycardia due to electrolyte changes as a pathomechanism of sudden cardiac death in chronic kidney disease patients undergoing hemodialysis.
In Heart Rhythm, vol. 15(5S) , pp. S354-S355, 2018
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A. Loewe, Y. Lutz, A. Fabbri, S. Severi, G. Seemann, and D. Dössel.
Influence of Electrolyte Concentration Changes on Sinus Node Function - A new Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?.
In Gordon Research Conference on Cardiac Arrhythmia Mechanisms, 2017
A. Loewe, Y. Lutz, M. Wilhelms, E. P. Scholz, O. Dössel, and G. Seemann.
Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Computing in Cardiology, vol. 41, pp. 745-748, 2014
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seeman.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Atrial Signals, 2015
A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Cardiac Physiome Workshop, 2015
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A. Loewe, E. Poremba, M. W. Krueger, O. Dössel, and G. Seemann.
Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning.
In TRM Forum, 2013
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, and O. Dössel.
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
In Computing in Cardiology, vol. 38, pp. 741-744, 2011
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A. Loewe, M. Wilhelms, O. Dössel, and G. Seemann.
Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014
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A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013
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A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents.
In Simula Cardiac Modeling Workshop, 2014
A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Emerging Mathematical Topics in Biology and Life Sciences, 2015
A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data.
In Cardiac Physiome Workshop, 2013
A. Loewe, Y. Xu, E. P. Scholz, O. Dössel, and G. Seemann.
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418–-422, 2015
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A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
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A. Loewe, E. Poremba, T. G. Oesterlein, N. Pilia, M. Pfeiffer, O. Dössel, and S. Speidel.
An interactive virtual reality environment for analysis of clinical atrial arrhythmias and ablation planning.
In Computing in Cardiology, vol. 44, 2017
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M. Alessandrini, M. Valinoti, A. Loewe, T. Oesterlein, O. Dössel, C. Corsi, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
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R. Andlauer, A. Loewe, O. Dössel, and G. Seemann.
Effect of left atrial hypertrophy on P-wave morphology in a computational model.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016
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L. Baron, A. Loewe, and O. Dössel.
From clinics to the virtual beating heart a general modeling workflow for patient-specific electromechanical heart simulations.
In BMTMedPhys 2017, vol. 62(S1) , pp. S70, 2017
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A. Daub, A. Loewe, and B. Frohnapfel.
Haemodynamics in an elasto-mechanic model of the human heart.
In Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 2018
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O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
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O. Dössel, and A. Loewe.
Computer Modelling pharmakologischer Effekte.
In Frühjahrstagung der Deutschen Gesellschaft für Kardiologie, 2017
A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Propagation of the primary pacemaker activity in the human heart: a computational approach.
In European Medical and Biological Engineering Conference (EMBEC), vol. 65, pp. 201, 2017
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A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Pace-and-Drive of the Human Sinoatrial Node – A Preliminary Computational Investigation.
In Computing in Cardiology, vol. 44, 2017
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M. Hernández Mesa, N. Pilia, O. Dössel, S. Severi, and A. Loewe.
Effects of Serum Calcium Changes on the Cardiac Action Potential and the ECG in a Computational Model.
In Current Directions in Biomedical Engineering, vol. 4(1) , pp. 251-254, 2018
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W. Kahlmann, E. Poremba, D. Potyagaylo, O. Dössel, and A. Loewe.
Modelling of patient-specific Purkinje activation based on measured ECGs.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 171-174, 2017
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H. Lehrmann, A. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel ECG-criteria For Real-time Assessment Of Anterior Mitral Line Block - “V1-jump” And “V1-delay”.
In Heart Rhythm, vol. 15(5S) , pp. S229, 2018
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J. Liu, A. Loewe, M. Zenge, A. Lefebvre, E. Mueller, and M. S. Nadar.
Elora: Enforcing Low Rank for Parallel MR Reconstruction.
In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013
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Y. Lutz, . Fabbri A., S. Severi, O. Dössel, and A. Loewe.
Plasma electrolyte concentrations in patients with chronic kidney disease influence cardiac pacemaking in a computational model.
In BMTMedPhys 2017, vol. 62(s1 - V71) , pp. 67, 2017
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Y. Lutz, A. Loewe, O. Dössel, and G. Seemann.
Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014
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N. Nagy, A. Loewe, Z. Kohaida, K. Halász, N. Tóth, J. Levijoki, P. Pollesello, T. Koskelainen, L. Otsomaa, A. Tóth, J. Gy, and A. Varró.
Selective Inhibition of the Cardiac Na+/Ca2+ Exchanger by a Novel Compound ORM-10962 Modulates Spontaneous Automaticity.
In European Working Group on Cardiac Cellular Electrophysiology, 2017
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T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
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N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
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N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
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D. Potyagaylo, A. Loewe, P. van Dam, and O. Dössel.
ECG imaging of focal atrial excitation: Evaluation in a realistic simulation setup.
In Computing in Cardiology, vol. 43, pp. 113-116, 2016
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M. Rottmann, L. A. Unger, W. Kaltenbacher, A. Loewe, M. W. Krueger, G. Seemann, T. Arentz, A. Jadidi, and O. Dössel.
Methods for Analyzing Signal Characteristics of Stable and Unstable Rotors in a Realistic Heart Model.
In Atrial Signals, 2015
M. Rottmann, L. A. Unger, W. Kaltenbacher, . Seemann G., A. Loewe, M. W. Krueger, A. S. Jadidi, T. Arentz, and O. Dössel.
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In Computing in Cardiology, vol. 42, pp. 485-488, 2015
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S. Schuler, L. Baron, A. Loewe, and O. Dössel.
Developing and coupling a lumped element model of the closed loop human vascular system to a model of cardiac mechanics.
In BMTMedPhys 2017, vol. 62(S1) , pp. S69, 2017
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W. H. W. Schulze, F. Elies Henar, D. Potyagaylo, A. Loewe, M. Stenroos, and O. Dössel.
Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
In FIMH, LNCS 7945, pp. 200-207, 2013
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G. Seemann, A. Loewe, Y. Lutz, M. Wilhelms, and O. Dössel.
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013
G. Seemann, A. Loewe, and E. M. Wülfers.
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
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G. Seemann, A. Loewe, and E. M. Wülfers.
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
S. Severi, A. Fabbri, M. Paci, R. Wilders, Y. Lutz, and A. Loewe.
Computational Modeling of the Cardiac Pacemaking in Humans.
In INdAM Workshop on Mathematical and Numerical Modeling of the Cardiovascular System, 2018
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E. Shin, E. Poremba, O. Dössel, and A. Loewe.
Automated Initiation of Fibrillatory Excitation in Monodomain Simulations.
In Kentucky Academy of Science , 2016
J. Trächtler, . Oesterlein T., A. Loewe, E. Poremba, A. Luik, C. Schmitt, and O. Dössel.
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015
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L. A. Unger, T. G. Oesterlein, P. Spector, A. Luik, C. Schmitt, A. Loewe, and O. Dössel.
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
L. Unger, T. Oesterlein, G. Seemann, O. Dössel, P. Spector, and A. Loewe.
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
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M. Valinoti, F. Bertoni, M. Alessandrini, R. Mantovan, A. Loewe, O. Dössel, S. Severi, and C. Corsi.
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation.
In Computing in Cardiology Conference, vol. 44, 2017
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B. Verma, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries.
In Computing in Cardiology, vol. 43, pp. 985-988, 2016
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A. Wachter, A. Loewe, M. W. Krueger, O. Dössel, and G. Seemann.
Mesh structure-independent modeling of patient-specific atrial fiber orientation.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 409-412, 2015
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E. M. Wülfers, A. Loewe, and G. Seemann.
A Computational Study on the Electrophysiological Effects of Fibroblasts Coupling to Human Atrial Myocytes from Different Regions.
In Cardiac Physiome Project, 2017

Dissertations (1)

A. Loewe.
Modeling human atrial patho-electrophysiology from ion channels to ECG : substrates, pharmacology, vulnerability, and P-waves.
KIT Scientific Publishing. Dissertation. 2016
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Student Theses (2)

A. Loewe.
Arrhythmic potency of human electrophysiological models adapted to chronic and familial atrial fibrillation.
Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT). Masterarbeit. 2013
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A. Loewe.
Comparison of cardiac simulation tools regarding the modeling of acute ischemia.
Institut für Biomedizinische Technik, Karlsruher Institut für Technologie (KIT). Bachelorarbeit. 2010
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